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Citalopram and Viagra Stack: Interaction and Effects

According to studies, about 35-50% of people who suffer from the major depressive disorder also experience some form of sexual dysfunction.

Citalopram and Viagra

Also, certain antidepressants like citalopram have the potential of causing sexual ailments or disorders [1]. Thus, a common solution to this problem is to add a drug that helps improve sexual function such as Viagra.

What Exactly Is Citalopram?

Citalopram is a prescription medication used to treat depression. It is sold under the brand name Celexa and is available in generic versions sold in different parts of the world. Citalopram is an antidepressant, and it belongs to the class of selective serotonin reuptake inhibitors (SSRI). It is used to treat several conditions such as panic disorder, social phobia, major depressive disorder, and obsessive-compulsive disorder [2].

Citalopram was approved in the United States in 1988, and ever since, its popularity has skyrocketed. As of 2016, it was the 21st most prescribed drug in the USA.

How It Works

Being a selective serotonin reuptake inhibitor (SSRI), citalopram acts in the human brain to cause an increase in the level of a natural substance known as serotonin. This increase in serotonin levels brings about improvements in the symptoms of depression [3].

Who Can Use It?

Citalopram can be used by adults and children over the age of twelve. However, it has to be on the basis of prescription. Patients who use it are often those who suffer from some form of depressive disorders such as major depressive disorder, obsessive-compulsive disorder, or social phobia.

What Is Viagra?

Viagra Drugs

Viagra (sildenafil) is a medication commonly used to fight erectile dysfunction in adult males [4]. This medication was discovered accidentally in 1989 by Pfizer while searching for a solution to heart-related chest pain. Subsequently, it was approved for medical use in the USA in 1998 [5]. Ever since its approval, this ED med has soared in popularity, and now it is the first choice for most men. It is worth noting that Viagra was the first ever oral medication to be approved for the treatment of erectile dysfunction.

How It Works

Viagra requires sexual stimulation to work. When a man is aroused, blood engulfs spongy tissues inside the penis, leading to an erection. Sometimes, certain medical conditions (diabetes, for example) can affect the way blood flows around the body. For men experiencing same or related issues, Viagra relaxes the walls of the blood vessels, increasing the blood flow to the penile region, and thus causes an erection.

How Long It Lasts

Viagra typically lasts for up to four hours. However, depending on one’s body’s metabolism, dosage, and several other factors, it may last longer [6]. Here are some factors that may affect the duration of Viagra’s effects:

  • Age. The metabolism of the human body typically slows down as one ages. Thus, as one gets older, ED medications last longer in their system (drugs in general). Men above the age of 65 typically experience the effects of Viagra for a longer period of time as opposed to younger individuals.
  • Dosage. The dosage determines how long this drug will stay in one’s body. For example, the 100 mg pill will definitely last longer than the 50 mg or the 25 mg dose. However, patients are advised against taking large doses in the bid to achieve prolonged effects. The consequences may be bad.
  • Nutrition and diet. What one consumes may equally affect the duration of this drug. Eating in large quantities or eating meals that contain fat before using Viagra may slow down the drug’s metabolism. In turn, slow metabolism could prolong its effects. Similarly, alcohol decreases the blood flow to the penis and can reduce the effectiveness and duration of Viagra if taken concomitantly.
  • Psychological state. One’s psychological state also determines how long Viagra stays in the body. If one feels depressed, stressed, nervous, or anxious, it may influence Viagra’s effectiveness or how long it lasts in the body. Thus, it is important to be relaxed when taking it.

It is evident that while Viagra has an average duration of four hours, this timeframe can be extended or reduced depending on the above factors. Thus, they must be taken into consideration when gauging Viagra’s effectiveness and the duration of its effects.

Usage of These Pills Stack

A large percentage of men taking antidepressants like citalopram often experience SSRI-induced sexual dysfunctions. As such, a common solution to alleviate such ailments is to combine the antidepressant with a medication for sexual dysfunction such as Viagra [1]. This will enable the patient to keep taking their drugs without having to deal with the sexual side effects that follow. According to studies, a significant percentage of men who had a major depressive disorder in remission as well as AASD and took Viagra reported an improvement in erectile function.

Take Pills Together

Thus, one can co-administer Viagra with citalopram to combat SSRI-induced sexual dysfunction. In the same vein, men who suffer from ED and depressive disorders can also co-administer these two medications. However, they should be used according to a doctor’s recommendation or prescription.

Safeness of Such Combination

When combining two or more medications, safety is a core factor that should be taken into consideration. However, this combination is quite safe as sildenafil is often co-administered with citalopram. According to a study carried out on the effects of the above-mentioned PDE5 inhibitor on antidepressant meds, low doses of sildenafil were found to enhance the antidepressant-like activity of citalopram. However, when the concentration of the latter was increased, an interaction was noticed [7]. Presently, further studies are required to ascertain the full extent to which sildenafil interacts with citalopram. As such, it is highly advisable to consult a doctor before co-administering both drugs.

Citalopram and Viagra Side Effects

While the coadministration of these meds enhances the antidepressant-like activity of citalopram as studies reveal, an interaction was also observed when the concentration of the mentioned SSRI was increased. This may mean that there could be certain adverse reactions if the doses are not gotten right. Nevertheless, more extensive research is required to understand the side effects that may result from concomitant use.

However, both drugs have negative reactions that may be experienced when used independently of the other.

For Viagra, the common side effects include:

  • flushing;
  • nasal congestion;
  • headache;
  • nausea;
  • dizziness.

However, in extremely rare cases, there may appear more serious side effects such as the following:

  • severely low blood pressure;
  • prolonged erections (priapism);
  • sudden hearing loss.

Low Blood Pressure

Any user who experiences any of these symptoms should seek urgent medical attention.

Citalopram, on the other hand, has a black box warning from the Food and Drug Administration (FDA). This kind of warning is quite serious and alerts users to dangerous side effects. This antidepressant may cause an increase in suicidal thoughts within younger users. It may also cause changes in heart rhythm [3]. Contact your doctor immediately if you notice any of these symptoms.

This antidepressant also has some more common side effects such as nausea, sleepiness, dry mouth, constipation, shaking, anxiousness, hunger, and weakness. However, they are usually found in adults. For children, common adverse reactions could include increased thirst, nose bleeds, and more frequent urination.

Withdrawal Time

There exists a possibility of experiencing withdrawal symptoms when using citalopram. This is why patients who want to stop using it are advised to avoid abrupt discontinuation. Rather, the dosage should be gradually reduced over the course of one or two weeks [8]. This will help to lower the risk of withdrawal reactions.

For many people, citalopram withdrawal symptoms begin to show within three to six days after the last dose and may last between five days to one month, or even longer.

On the other hand, there is no scientific proof or study that shows evidence of Viagra addiction. Hence, there is no info on Viagra withdrawal time.

Interaction with Food and Alcohol

Citalopram and Viagra interact with certain foods, medications, and alcohol. As such, it is important to apply caution when using any of these drugs so as to avoid any negative interaction.

Some of the meds citalopram interacts with in a harmful way include NSAIDs such as ibuprofen and blood thinners (e.g., warfarin). These drugs may cause bleeding or bruising when used concomitantly with this antidepressant. MAO inhibitors like isocarboxazid (Marplan), selegiline (Eldepryl, Zelapar), tranylcypromine (Parnate), and phenelzine (Nardil) are also to be avoided when taking citalopram.

Taking other SSRIs or serotonin-increasing medications when using citalopram may lead to serotonin syndrome/toxicity.

Viagra, on the other hand, should not be taken too frequently by people who use protease inhibitors as it can lead to the multiplication of sildenafil plasma levels. This can ultimately increase the severity and risks of side effects. It also interacts with nitrates and alpha-blockers.

Always list all of the prescription and otc medication you’re currently taking when visiting your healthcare professional before administering citalopram or Viagra.

Avoid drinking alcohol while on any of these meds, and do not consume grapefruits or grapefruit products while taking Viagra.

What Are the Best Places to Buy These Medicines?

Citalopram and Viagra can be purchased from any reputable walk-in pharmacy. However, most people prefer to buy tabs online because of the convenience and discounts and bonuses often associated with it.

Online Purchase

Here are some of the best online pharmacies to buy one or both of these drugs.

ViaBestBuys

ViaBestBuys sells a variety of medications to customers with no prescription needed. This drugstore provides mouth-watering deals, discounts, and offers. For example, clients who place orders using bitcoins as a payment option automatically get 35% off, however, if you don’t use crypto, you can check out with a credit card or PayPal. Returning customers get $25 off, and users who review the website get $30 off their order.

ViaBestBuys ships packages from India using either Express Mail Service (EMS) or Registered Airmail. EMS is employed for the delivery of orders from New Zealand, Australia, the United Kingdom, and the USA, and it usually takes 7-10 business days. Delivery to other countries usually takes 14-30 days.

Registered Airmail shipping, on the other hand, is used to fulfill bulky orders. It’s usually slower, taking 10-18 business days for delivery to the above-listed countries and 14-30 days to other parts of the world. While most other vendors seldom ship bulky orders due to customs regulations, this seller makes it possible by splitting the order into smaller parcels and shipping them out 3-5 days apart.

There are a few countries ViaBestBuy does not ship directly to as a result of their import laws; they include Israel, Canada, Mexico, Indonesia, Brazil, and Pakistan. However, individuals in these places can use a good reshipping service like SkyPax.

CialisBit

Like ViaBestBuy, CialisBit ships ED treatments from India to its clients through either EMS or Registered Airmail. The delivery speed may vary depending on the destination country and the shipping option selected. For example, EMS shipments to New Zealand, the US or the UK may take within 7-10 business days to get delivered. CialisBit ships to above-listed locations including Austria, Australia, and all countries in the EU.

This vendor offers amazing discounts via coupon codes and vouchers. For example, it rewards users who pay via bitcoin with up to 35% off. CialisBit also accepts credit card payments. However, it does not ship to certain countries due to stringent laws. These countries include Taiwan, UAE, Mexico, Brazil, Israel, Canada, South Africa, and Saudi Arabia among a few others.

HighStreetPharma

HighStreetPharma sells generic versions of both medications at really low prices with no doctor’s prescription required. It offers 25% discounts to customers who make payments with crypto, but you also have the option to pay with a gift card.

It ships to different parts of the world and ensures that its customers’ privacy is protected by using only plain, discreet packaging. Countries it ships to include Algeria, Austria, Armenia, Brazil, Belgium, Croatia, China, Denmark, Czech, Israel, Germany, India, Iceland, Italy, Indonesia, Jordan, Japan, the Netherlands, Mexico, Poland, New Zealand, Norway, Russia, Serbia, Saudi Arabia, Taiwan, Sweden, Pakistan, Hungary, UAE, and South Africa. However, it does not provide refunds or reshipment to these locations due to their strict customs laws.

HighStreetPharma offers 2 shipping options. EMS takes 7-14 days, while Airmail usually takes 7-14 days. This pharmacy provides free Airmail shipping to customers who order products worth 150 USD. Individuals in locations not listed on the site can use a forwarding service provider like SkyPax.com

PureRxPills

This vendor is a pharmaceutical intermediary and it’s rated among the top 10 online pharmacies and sells quality drugs at low prices. It does not require a doctor’s prescription before selling generic versions of many popular medications, however, each order is reviewed by a licensed physician to ensure the safety of the buyer.

One can check out safely and securely there using any major credit card. If purchasing from PureRxPills, you’ll most likely be eligible for free global shipping via Registered Airmail and offered a refund or reshipping if the package gets damaged. There are no returns though.

Resume

Citalopram is an effective antidepressant that can be used in adults and children above the age of 12. However, using it consistently may cause sexual dysfunction. Thus, those taking it to treat depressive disorders may combine it with Viagra to combat both conditions effectively. However, it is important to seek medical advice before beginning treatment with any of these drugs or combining them.

References:

  1. Dealing with sexual side effects of antidepressants. Retrieved: February 11, 2020. Health.harvard.edu.
  2. Citalopram. Retrieved February 10, 2020. En.m.wikipedia.org.
  3. Citalopram | Side Effects, Dosage, Uses and More. By the University of Illinois-Chicago. Retrieved: February 11, 2020. Healthline.com.
  4. Sildenafil: Drug Information. Retrieved: February 11, 2020. Medlineplus.gov.
  5. Viagra: How a Little Blue Pill Changed the World. Medically reviewed by L. Anderson, PharmD. Retrieved: February 11, 2020. Drugs.com.
  6. How Long Does Viagra Last: Effects in Your System. By Tim Jewell. Medically reviewed by Alan Carter, Pharm D. Retrieved: February 11, 2020. Healthline.com.
  7. Effect of Sildenafil on the Activity of some Antidepressant Drugs and Electroconvulsive Shock Treatment in the Forced Swim Test in Mice. By Katarzyna Socała, Dorota Nieoczym et. al. Naunyn Schmiedebergs Arch Pharmacol. 2017; 390(4): 339–349. Retrieved: February 11, 2020. Ncbi.nlm.nih.gov.
  8. Citalopram 20mg Tablets – Summary of Product Characteristics. Retrieved: February 11, 2020. Medicines.org.uk.