Difference Between PT-141 and Cialis Drugs

In today’s world where there is an influx of treatments for erectile dysfunction (ED), distinguishing between the safe and potentially dangerous medications can be quite complicated. In fact, one may even be tempted to believe that these drugs are one and the same.

However, it is important to note that even though most of these meds serve the same purpose, they can be quite different. This article will carefully analyze both drugs, their usage, similarities as well as differences, and draw a comparative analysis between them both.

What Is PT-141 Medicine?

Also known as bremelanotide, PT-141 is popularly used to treat sexual ailments or dysfunctions in both men and women. It is a melanocortin-based peptide developed from the Melanotan II peptide, which was initially tested as a tanning agent. However, its function as a treatment for sexual ailments was later discovered by accident.

In the early 1960s, studies and experiments showed that α-MSH caused a level of sexual arousal in rats when administered to them [1]. This finding ignited a deep interest in α-MSH, and thus, in the 1980s, scientists at the University of Arizona began to develop it as a potential tanning agent. These experiments involved the testing of analogs such as Melanotan I and Melanotan II.

Not long into the experiment, a scientist known as Mac Hadley who was experimenting with the peptide, Melanotan II, injected himself with an accidental double dose. This led to a raging eight-hour-long erection in addition to side effects such as nausea and vomiting [2].

Thus, this peptide began to undergo a series of clinical trials and development. In subsequent phases of its clinical trial, it was tested on premenopausal women, and the findings showed that it was effective in treating sexual arousal disorders.

How It Works

PT-141 works in a way different from other ED medications such as Viagra and Cialis. Instead of operating in the vascular system alone, it focuses on increasing sexual desires through the nervous system [2]. When taken, PT-141 helps to stimulate and equally activate the dopamine hormones in the user’s body. Dopamine is a compound in the human body. It is also a neurotransmitter that helps to stimulate sexual desire. Reduced levels of dopamine in the body will lead to low libido. As such, PT-141 helps to boost the libido by activating the dopamine hormones, thereby leading to increased sexual performance.

In the same vein, PT-141 can also be used as a natural energy booster. It also serves as an effective and safe tanning agent, saving users from having to experience the harmful effects of sunlight and UV radiation.

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Is It Safe?

According to a placebo-controlled evaluation of PT-141, this medication is quite safe, well-tolerated and comes with minimal adverse events. The most common side effects reported were cases of nausea, flushing, and feeling hot. These reactions were resolved without treatment or medical intervention. There were no clinically significant changes in heart rate, blood pressure, or ECG evaluations [3].

What Exactly Is Cialis?

Cialis is a highly rated medication used in the treatment and management of erectile dysfunction in adult males. With tadalafil as its active component, this drug is also effective in combating benign prostatic hyperplasia and pulmonary arterial hypertension. It was approved by the Food and Drug Administration (FDA) in 2003 for the treatment of erectile dysfunction (ED) [4].

Since its introduction to the pharmaceutical market, Cialis has made waves as a very effective treatment for impotence and, in some cases, premature ejaculation. Due to its long-lasting effect, it has become the favorite ED remedy for most men.

According to studies and actual user reviews, the effects of Cialis typically last for up to thirty-six hours, which earned it the nickname “The Weekend Pill” among users. However, this effect is often misinterpreted. While Cialis may last for up to thirty-six hours, the user will not experience an erection for thirty-six hours in a row. Rather, he would find it easier to gain and sustain improved erections within this timeframe.

How It Works

Its active ingredient, tadalafil, is responsible for improving and enhancing erections in users.

Usually, a penile erection occurs when the penis is filled with blood. This is usually caused by the dilation of the blood vessels that carry blood flow to the penis. This dilation thereby causes an increase in blood supply. During the dilation, the other blood vessels that are responsible for removing blood from the vessels contract, causing blood to accumulate in the penis that ultimately results in an erection.

During sexual stimulation, nitric oxide is released into the penis. Nitric oxide is responsible for the production of cGMP which in turn controls the dilation and contraction of the blood vessels that carry blood to and away from the penis [5].

However, a class of enzymes known as phosphodiesterase type 5 (PDE5) destroys cGMP, causing the blood vessels to return to their normal state and size. This results in the end of the erection. Thus, tadalafil blocks the actions of the PDE5 enzyme, thereby leading to enhanced and prolonged erections.

Is It Safe?

Cialis is a well-tolerated and safe medication. However, as with any other medicine, there may be side effects associated with its use. Also, it may not be suitable for certain users. For example, those with an underlying medical condition. Thus, it is important to consult a doctor in order to ascertain how safe it is for you before beginning treatment with it.

In the same vein, overdosing is a highly discouraged practice as it may increase the risk of harmful side effects. Consult a doctor if symptoms persist.

Cialis vs PT-141 Comparison

PT-141 vs Cialis is a common, debatable subject. To make comparing them easier here is a tabular analysis of the qualities of both medications.

Brand Name	Cialis	PT-141
Is there a generic version?	Yes	Yes
What is the generic name of this medication?	Tadalafil	Bremelanotide
What form does it come in?	Oral tablet	Subcutaneous injection
Available strengths	2.5 mg, 5 mg, 10 mg, 20 mg	Comes in a 10 mg vial, which can be broken down into smaller doses
Typical dosage	2.5 mg (when taken daily) and 10 mg (when taken as needed)	2 mg
When to take it?	Thirty minutes before sex	One hour prior to sexual activity
Duration of its effects	Up to thirty-six hours	Between six to seventy-two hours

It should be noted that although PT-141 may come in other forms such as pills or nasal sprays, they are not legitimate. A subcutaneous injection is the only legitimate form of this medication [6].

Best Places to Buy These Medications

Both Cialis and PT-141 are available in various pharmacies either online or offline. However, walk-in or brick-and-mortar drugstores may not be a popular choice among users as most of them require a doctor’s prescription and are usually more expensive.

Thus, many users simply turn to reliable and genuine online pharmacies for their ED-related needs. Here are some of the best places where one can buy these medications.

ViaBestBuys

ViaBestBuys is one of the most popular and highly rated online vendors. This e-pharmacy offers a wide range of treatments and medications for erectile dysfunction. It accepts credit card payments as well as Bitcoin and PayPal. In addition, customers get to enjoy amazing discounts and deals. For example, they can get 25% off their purchases when making payments with Bitcoin. ViaBestBuys does not require a doctor’s prescription from customers.

This vendor dispatches all orders within two hours after payment has been confirmed. Subsequently, customers receive an email containing a tracking notification. This email usually comes within two days, so buyers may need to be patient.

ViaBestBuys offers two delivery options. These are as follows:

• Express Mail Service (EMS). This is the fastest shipping option. Packages ordered from Australia, New Zealand, the United States, and the United Kingdom with this option usually arrive within 7-10 business days, whereas those to other countries may take 14-30 business days. This service costs $49 but is completely free if the customer places an order worth $180.
• Registered Airmail. This delivery option is slower than express shipping but is quite cheaper. Orders placed from the aforementioned countries with this option take 10-18 business days, while those to other countries may take 14-30 days. It costs $39 but is completely free if the customer buys medications worth over $130. This option is perfect for bulk orders, especially from countries with stringent import laws. For such orders, the package is split into smaller parcels and shipped 3-5 days apart.

This vendor does not ship to Indonesia, Israel, Mexico, Canada, Pakistan, Brazil, and some other countries. However, people there can get products delivered by using a parcel forwarding service like SkyPax.

ViaBestBuys provides a full refund or reships packages in the event that they are delayed at customs for more than 2 weeks or get missing.

CialisBit

CialisBit is a close competitor to ViaBestBuys as these two pharmacies share a lot of similarities.

The acceptable payment methods here are credit cards, PayPal, and cryptocurrency (which can get you a 25% discount). CialisBit also ships all orders from India using two shipping options:

• Express Mail Service (EMS). With this delivery, orders made from New Zealand, Australia, the UK, and the USA take within 7-10 business days, while those to other parts of the world may take 14-30 business days. EMS does not require a signature upon delivery, and customers typically get their tracking number within 24-72 hours after purchase.
• Registered Airmail. This shipping option is best for bulk orders or delivery to countries with strict import laws. It takes between 10-18 business days for orders from Australia, New Zealand, the United Kingdom, and the USA. For other parts of the world, it may take up to 14-30 days. Orders made with this shipping option are not trackable.

Usually, customs clearance is obligatory and may take between 1-2 days. In the event that a package gets stuck at customs for up to two weeks or gets lost, this vendor provides a complete refund or reships the package.

CialisBit does not ship to the following countries:

• Canada;
• Mexico;
• Indonesia;
• Pakistan;
• Brazil;
• Israel;
• Taiwan;
• Saudi Arabia;
• the United Arab Emirates;
• South Africa;
• and a few others.

Customers living in countries with stringent customs and import laws can use a reshipping service such as SkyPax.

HighStreetPharma

This is yet another reputable online pharmacy that offers a variety of medications for erectile dysfunction and other medical conditions. HighStreetPharma has several approved fulfillment centers all over the world from which it ships and fills medication orders. These centers are located in countries such as India, New Zealand, Mauritius, the United States, and the United Kingdom.

It does not require a doctor’s prescription before selling to customers. This vendor also offers EMS and Registered Airmail as its shipping options. Orders made using EMS typically arrive within 7-14 days. On the other hand, Registered Airmail may take between 14-21 days.

HighStreetPharma accepts Gift Cards and Bitcoin payments and offers free shipping via Airmail to those who have a minimum order value of $150.

PureRxPills

PureRxPills provides customers with an easy and seamless way of ordering ED medications or any other drug for that matter. It has a beautifully designed website that is easy to navigate, add drugs to cart, and make a payment. However, this vendor requires customers to fill a patient profile form that will be sent to a certified physician for reviewing and approval.

PureRxPills values customer privacy and as such ensures that its clients enjoy anonymity and protected information. It accepts credit card payments, and the process is SSL-secured. It ships with the Registered Airmail, and most orders are eligible for free delivery. This, however, depends on the case.

What Dosage Have These Drugs?

Cialis comes in various strengths, which include 2.5 mg, 5 mg, 10 mg, 20 mg. However, the recommended dosage is 2.5 mg for users who want to take it daily. When taking it randomly before sexual activity, the recommended dosage is 10 mg to experience maximum positive and minimal negative effects.

On the other hand, PT-141 typically comes in a 10 mg vial size. The recommended dosage for this medication is 2 mg. To be exact, 1 mg is to be first injected as a test dose 1 hour before sex and then the remaining 1 mg 30 minutes after [6].

PT-141 vs Cialis Side Effects

PT-141 and Cialis have similar side effects. However, the former’s adverse reactions can be said to have an atom of difference when compared to the latter.

In the trials, symptoms such as headache, nausea, and flushing were observed to accompany the usage of PT-141. These side effects had varying intensity levels, ranging from mild to moderate. In the same vein, this drug may also cause itchiness, reddening, bumping, and pain at the injection site. An increase in the rate of sexual arousal is another common side effect that may be experienced with it. However, the reactions may differ from person to person.

On the other hand, Cialis may come with side effects such as headaches, nausea, flushing, back pain, muscle pain, stuffy nose, and dizziness [7]. Serious negative reactions may include priapism and sudden loss of vision. It is worth noting that this does not contain all the possible reactions associated with this drug. Consult a doctor for a more updated list of side effects.

Interactions with Other Medicines

PT-141 does not necessarily interact with alcohol. However, it may interact with certain oral medications such as naltrexone and indomethacin by reducing their oral absorption (bioavailability). Always check with your doctor, whether you can consume this drug in addition to other meds you’re taking.

Cialis, on the other hand, interacts with nitrates such as nitroglycerin or isosorbide dinitrate. Amlodipine, metoprolol, and lisinopril are some other drugs it interacts with. In general, this med is known to interfere with over 247 drugs, with 9 major, 140 moderate, and 98 minor negative interactions [8]. Cialis interacts with certain medical conditions like hearing loss, cardiovascular disease, liver damage, etc. Excessive alcohol consumption is also known to affect its efficacy.

Consult a physician to learn more about substance these drugs may interact with.

Conclusion

PT-141 and Cialis are two highly effective treatments for erectile dysfunction in adult males. However, a lot of people seem to prefer the latter probably because PT-141 involves the use of injections. One or the other may not be suitable for you depending on a number of factors such as other medicines you may be taking (prescription and over-the-counter), underlying health conditions, or drug history. Whichever the case, a doctor may tell you which will best fit your needs.

When using any of these medications, it is important to consult a doctor and purchase them from only reliable pharmacies.

References:

1. PT-141: a melanocortin agonist for the treatment of sexual dysfunction. By Molinoff PB, et al. Ann N Y Acad Sci. 2003. Retrieved: February 14, 2020. Ncbi.nlm.nih.gov.
2. Melanocortin Receptors, Melanotropic Peptides, and Penile Erection. By Stephen H. King, et al. Curr Top Med Chem. 2007; 7(11): 1098–1106. Retrieved: February 14, 2020. Ncbi.nlm.nih.gov.
3. Evaluation of the safety, pharmacokinetics and pharmacodynamic effects of subcutaneously administered PT-141, a melanocortin receptor agonist, in healthy male subjects and in patients with an inadequate response to Viagra. By Rosen RC, et al. Int J Impot Res. 2004. Retrieved: February 14, 2020. Ncbi.nlm.nih.gov.
4. Cialis (tadalafil) FDA Approval History. Retrieved: February 14, 2020. Drugs.com.
5. Cialis: How it Works, Uses, Side Effects, and Interactions. By Alan Carter. Medically Reviewed by Alan Carter. Pharm.D. Retrieved: February 14, 2020. Medicalnewstoday.com.
6. PT 141 Guide- Benefits, Side Effects & Dosage. By Dr. Majed. Retrieved: February 14, 2020. Slcompounding.com.
7. Cialis Oral: Uses, Side Effects, Interactions, and Precautions. Retrieved: February 14, 2020. Webmd.com.
8. Cialis (tadalafil) Drug Interactions. Retrieved: February 14, 2020. Drugs.com.