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What’s propranolol and Viagra used for? Before mixing drugs, it’s very important to understand various drug uses, side effects, interactions, as well as the benefits they reward when combined.
This guide is equipped with pointers of coadministering Viagra and propranolol and what are the effects to expect. For interested individuals who need to get their hands on Viagra, this guide gives useful indicators on the best e-pharmacies where you can buy quality & genuine medicine at extremely low prices.
Let’s get started!
Table of Contents
Some Info About Viagra
Viagra is a branded drug containing the active ingredient – sildenafil citrate. It is manufactured by Pfizer and has been available as a treatment since 1998 [1].
The active substance is used for two main purposes:
- as a remedy for erectile dysfunction (ED). In combination with sexual stimulation, Viagra (sildenafil) works by increasing blood flow to the penis to help a man affected by ED get and keep an erection; and
- to treat pulmonary arterial hypertension (PAH) and effectively improve exercise capacity in patients affected by this condition.
Being the most famous and popular male impotence drug, Viagra is highly effective and well-tolerated, especially for people with good health. Before initiating the dosage, it is recommended to first consult with a medical specialist to assess your health in order to avoid serious drug reaction & possible drug interaction, which might cause harm to your health.
With the availability of generics, Viagra is the most counterfeited med sold over the counter from illegal online vendors. It’s necessary to only get the approved Viagra med, either its generic or brand-name version, from reliable manufacturers.
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What Is Propranolol?
Propranolol is a non-selective beta-receptor blocker. It works on the lungs, heart and other areas of the body in a similar way. Its function is to lower blood pressure, but how exactly it does so – is not clearly understood. Nevertheless, it lightens the workload of the heart and blocks the release of renin from the kidneys.
It is sold under the brand name Inderal. It comes in four forms: oral tablet, oral liquid solution, extended-release oral capsule, and injectable [2].
Propranolol oral tab reduces the patient heart’s workload and helps it beat/function more regularly. This pharmaceutical is used to treat the following health conditions:
- hypertension;
- tachyarrhythmia;
- tension headache (off label use);
- glaucoma;
- angina pectoris;
- myocardial infarction;
- essential tremor;
- shaky hands;
- primary exertional headache.
In addition, propranolol is prescribed for the prophylaxis of migraine and cluster headaches and for the control of tachycardia/tremor.
Like any other meds, consulting with a doctor and taking the drug exactly as prescribed are paramount. Safe medication means adhering and following all directions on drug prescription labels. Your medical specialist may occasionally alter your dose to make sure you get the best results.
Can You Take Viagra and Propranolol Together?
Sildenafil and propranolol are used to treat different medical conditions.
Sildenafil is an oral med belonging to the drug class called phosphodiesterase-5 (PDE5) inhibitors approved for the treatment of pulmonary arterial hypertension (PAH). However, it is also marketed as Viagra among other generics that are FDA-approved for the treatment of male impotence but not for the treatment of PAH [3].
By understanding how these meds work, it’s easy to consider their ability to function without causing problems.
Sildenafil acts to dilate (or widen) the walls of the arteries, increasing blood flow and reducing the strain on the heart. Beta-blockers like propranolol work by blocking the effects of the hormone epinephrine (adrenaline), making the patient’s heart beat more slowly and with less force. This effect lowers blood pressure and also helps open up the patient’s veins and arteries to improve blood flow.
Propranolol and Viagra both have a chance of lowering blood pressure when coadministered. Major drops in blood pressure have been known to happen when sildenafil is combined with other blood pressure meds but not when mixed with the class of other drugs to which propranolol belongs.
In this regard, Viagra is not a daily dose. It’s only taken as needed but not at the same time when taking other drugs exerting a similar effect on the same body organs or system.
No reports have shown a decrease in blood pressure due to the combination of beta-blockers and PDE5 inhibitors, which is significant enough to cause serious harm. Therefore, a mix of Viagra and propranolol is probably not too dangerous. However, this evidence is anecdotal and cannot be held clinically relevant. Always talk to a medical specialist when taking a new drug [4].
For safe medication, consult with a doctor and try these meds in a controlled setting to make sure that this combination is good for you [5].
Furthermore, according to the research, when taking Viagra for ED together with propranolol, the latter can inhibit the effect of sildenafil at all frequencies of stimulation and potentially mask its impact on erectile function [6].
Possible Side Effects of Mixing
As aforementioned, it’s not yet clinically established, whether you can take these two meds at the same time. Creating time intervals is needed if it’s necessary to coadminister the two meds.
Sildenafil can contribute to the blood pressure-lowering effect of propranolol. Contact your medical specialist if you experience signs and symptoms of low blood pressure such as the following:
- feeling dizzy or lightheaded;
- fainting;
- headache;
- flushing;
- pulse speeding up.
The above issues occur most often at the beginning of treatment, especially following a dose increase or when medication is restarted after an interruption [7].
Note that individual drugs can also induce side effects. Depending on the patient’s health condition and drug prescriptions, negative reactions can be serious and life-threatening. It’s necessary to indeed adhere to drug prescriptions and precautions in order to lower the chances of serious side effects.
Withdrawal Period of These Medicines
Viagra has a short withdrawal period. Its long-term efficacy, the safety of this medication were evaluated in men with ED along with the effect of withdrawing treatment, according to research.
Oral sildenafil is highly effective and well-tolerated both at the start of therapy and during long-term treatment. Most patients have to continuously take Viagra before each intercourse for improvements in erectile function to be maintained [8].
Viagra leaves the individual body system after 2 to 3 hours. Depending on patient metabolism, this med usually takes 5 to 6 hours to fully leave the body system. However, a higher dosage (100 mg) will take longer to leave the body. A 25 mg dose may wear off after a couple of hours.
As to how long sildenafil lasts, it depends on individual dosage, age, diet, medication, overall health, and psychological state among other conditions.
The plasma half-life of propranolol is from 3 to 6 hours. Propranolol withdrawal in patients who have received this med for a considerable period might unmask a progression of the disease process. In the absence of beta-blockade, the supply of oxygen is inadequate [9]. Withdrawal should be gradual over 10-14 days with the help of a medical specialist [10]. Do not stop medication alone. Abruptly stopping propranolol may lead to withdrawal syndrome.
Stopping any beta-blocker may cause a response ranging from mild to very severe. It can result in a rise in blood pressure, and in patients with heart disease, heart attack, or chest pain, it can worsen the problem or can lead to sudden death [11].
Propranolol and Viagra Plus Alcohol and Food
It’s necessary to let a doctor assess your health for possible diseases that might cause interaction as well as identify the meds you take – either herbal remedies, vitamins, herbs, or OTC/prescription meds.
Propranolol, just like Viagra, causes serious interference with other meds and negatively affects the patient’s health if not assessed. Full info about Viagra dosage, warnings & precaution, as well as interaction, is found from the product source of patient prescribing information [12].
Viagra’s effects are affected by eating a large meal or a lot of high-fat foods right before administering this med. Food can keep sildenafil from being metabolized quickly or effectively. Also, avoid the regular taking of large amounts of grapefruits/grapefruit juice. These products can raise the levels of sildenafil in the body and delay its onset of action.
Moreover, alcohol can worsen the side effects of Viagra. Taking alcohol while on Viagra can decrease blood flow to the penis, making the drug less effective or shorter-lasting.
Notably, meals can enhance the levels of propranolol in the body. The patient should take this med at the same time each day, preferably with or immediately following meals. This aspect makes it easier for the body to absorb the medication.
Nonetheless, avoid drinking alcohol as it could increase dizziness and drowsiness while taking propranolol. This medicine is only part of a complete treatment therapy that also includes exercise, diet, and weight control [13].
Where to Order These Drugs?
That has been a long review of mixing these drugs. With full info, patients interested in getting Viagra tablets to treat ED or using propranolol to medicate health problems with the help of a prescription from a doctor can wonder where they can source any of these meds.
Here is the list with necessary info on legit and highly rated e-pharmacies. All of them are selling Viagra, and one offers propranolol too.
ViaBestBuys.com
ViaBestBuys is an online drugstore selling various meds to treat impotence. The good news is that ViaBestBuys only sources approved ED drugs from reliable manufacturers.
This ED medicine is priced at the manufacturing cost. Unlike other online vendors pricing meds slightly higher, this e-pharmacy should be your ultimate stop for all things quality and approved ED meds.
From this supplier, the shipping of meds is global except a few listed countries including Canada, Mexico, and Brazil among others. What more can you ask from this vendor? It offers two delivery options:
- standard shipping, which takes 10-18 business days at a charge of $39 – free for orders over $130;
- Express Mail Service (EMS) taking from 7 up to 10 business days and worth $49 but free for orders above $180.
In case of your package held at the customs, don’t worry, this vendor will have it reship or offer a full refund – whichever you prefer.
What’s more from this drugstore? Think of its payment options. You can check out with PayPal, a credit card, American Express, and, most interestingly, with Bitcoin (BTC), which earns you a 25% discount.
With its low pricing of meds, you can save more with time-to-time exclusive customer-tailored price-reducing experiences such as discounts. If you are looking for the cheapest e-pharmacy, ViaBestBuys is the ultimate vendor.
CialisBit.com
This is a highly rated and well-recommended e-pharmacy offering various approved generic meds including Cialis, Viagra, and other male impotence pharmaceuticals.
This vendor sells its pharmaceuticals at a lower cost. In regards to getting genuine and quality Viagra, CialisBit sources it only from the right manufacturers that are approved to sell health products.
The cost of Viagra offered by this vendor is extremely low. Customers also enjoy various price-reducing experiences such as offers, coupons, and discounts. You can save 25% off your total cost when checking out with Bitcoin. However, one can also pay with PayPal or any major credit card.
Worried about shipping methods and time? CialisBit ultra-fast shipping is global. However, due to strict customs laws, delivery to Canada and some other countries is not possible due to the strict importation regulations and customs laws.
From this vendor, delivery of Viagra and other ED meds is free for orders over $130 for standard shipping, which takes 10-18 business days. Also, the EMS delivery option, which takes 7-10 business days, is free for orders over $180.
HighStreetPharma.com
This e-pharmacy offers a wide range of health treatments from different categories including ED, HIV, weight loss, hair loss, diabetes, and a lot more. As the drugstore states, its products including Viagra and propranolol are genuine as it sources them from approved manufacturers. The payments are ought to be made with a gift card or crypto.
HighStreetPharma delivers its products to most parts of the world. However, it does not guarantee 100% delivery to the few listed countries due to various country-specific strict customs. If by fate your package failed to be delivered to destinations mentioned on the website, this vendor does not offer refunds or reshipments. Nonetheless, for other countries, HighStreetPharma offers two shipping options:
- EMS – which takes 7-14 days;
- Airmail – taking 14-21 days.
Above all, this legit and trusted online vendor provides free Airmail shipping for ED orders above $150.
PureRxPills.com
Like the aforementioned e-pharmacies, PureRxPills does its business by satisfying customers with approved, genuine, and quality meds at affordable prices. Ordering Viagra or other pills from this vendor is simple and fast.
PureRxPills is highly rated among the top-10 e-pharmacies, having nearly five thousand positive customers’ reviews and testimonials.
Interestingly, PureRxPills functions on a prescription-free basis, however, one needs to fill in the questionnaire that is forwarded to a licensed physician to assess the client’s health condition. It also provides a convenient and secure payment experience by accepting Visa and MasterCard. Buying pharmaceuticals from this supplier is 100% risk-free and its global delivery is ultra-fast.
Promisingly, most of the purchases made from this e-pharmacy are eligible for free worldwide delivery using Registered Airmail. Nonetheless, unlike the aforementioned e-pharmacies, PureRxPills has no list of countries it does not deliver to, so one has to contact customer service in case of any questions.
Recap
This has been a comprehensive outlook of propranolol vs Viagra drug mixing. While various sources claimed these meds can be combined, precaution should come first. Mixing drugs while having various health problems may reduce drug efficacy and can lead to major, moderate, or minor interactions.
Letting a doctor prescribe you both products with possible drug adjustment is necessary. Viagra is highly potent in treating ED and works well for healthy people. Taking propranolol should be administered with caution after approval from a doctor.
References:
- Viagra. Retrieved: February 19, 2020. Viagra.com.
- Propranolol. Retrieved: February 19, 2020. Wikipedia.org.
- Sildenafil (Revatio®). Treatments for Pulmonary Hypertension. Updated November 2013. Retrieved: February 19, 2020. Phassociation.org.
- Can you take propranolol and Viagra together? Retrieved: February 19, 2020. Justanswer.co.uk.
- Can I take Viagra (sildenafil) with propranolol? Retrieved February 19, 2020. Healthtap.com.
- Combined effect of sildenafil and guanethidine, propranolol or verapamil on erectile function in rats. Senbel AM, Hashad AM, Sharabi FM, Daabees TT. J Pharm Pharmacol. Published: November 2012. Ncbi.nlm.nih.gov.
- Drug Interactions between Inderide and Viagra. Retrieved: February 19, 2020. Drugs.com.
- Long-term efficacy and safety of oral Viagra (sildenafil citrate) in men with erectile dysfunction and the effect of randomised treatment withdrawal. Christiansen E, Guirguis WR, Cox D, Osterloh IH. Published: June 2000. Ncbi.nlm.nih.gov.
- Withdrawal of beta-blocking drugs. Walden RJ, Hernandez J, Yu Y, Al-Khader A, Prichard BN. Am Heart J. Published: August 1982. Ncbi.nlm.nih.gov.
- Propranolol 10mg, 40mg, 80mg and 160mg tablets (pdf). Retrieved: February 19, 2020. Ncbi.nlm.nih.gov.
- 10 Medications That Are Dangerous to Stop Abruptly. By Sharon Orrange, MD, MPH. Published: October 10, 2019. Goodrx.com.
- HIGHLIGHTS OF PRESCRIBING INFORMATION. Retrieved: February 19, 2020. Labeling.pfizer.com.
- Drug Interactions between Inderide and Viagra. Retrieved: February 19, 2020. Drugs.com.
Head Researcher