Cialis and Poppers Stack: Interaction and Effects

For most teenagers and certain adults even, poppers are one of the most easily accessible club substances. While they can be easily bought as leather cleaners or deodorizers that they’re seldom used as, they pose very serious health risks to people who inhale them, especially when combined with Cialis or other erectile dysfunction (ED) drugs.

What Exactly Are Poppers?

Popper is a blanket term given to a range of psychoactive drugs of the chemical class called alkyl nitrites. It is commonly used as a recreational medication for achieving the “high” that it creates when inhaled as well as for increasing sensations during sexual intercourse. Its unique term, “popper,” originated from its packaging (a glass vial) that makes a popping sound when cracked open.

When inhaled, they cause the smooth muscle cells in arteries to relax. This brings about an increase in blood flow and a corresponding decrease in blood pressure accompanied by increased heart rate [1].

These drugs are so common within the gay community that they are widely thought of as gay drugs. Because poppers increase blood flow to involuntary muscles such as those of the anus and throat, bringing about relaxation, they are used to facilitate anal penetration. These substances are often used by people who intend to experience an intense rush, mood elevation, relaxation, and a feeling of euphoria [2].

In some countries, poppers are sold as air fresheners because of their fruity and welcoming aroma. In the US, this class of drugs is often sold as a nail polish remover and a leather cleaner [3]. Though poppers can be very harmful, they are cheap and easy to come by. These products usually come in vials that range from 10-30 milliliters.

Poppers were formally approved for use as a prescription drug by the FDA (Food and Drug Administration). Later in the year 1960, they were deemed safe for use and therefore allowed to be bought over the counter. However, this privilege was short-lived as these products were banned due to their increased use as a recreational drug [4].

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What Is Cialis?

Cialis is a medication with tadalafil as its active ingredient, used in the treatment of erectile dysfunction (ED) in men. In the year 2003, it was approved for this purpose by the Food and Drug Administration (FDA). Cialis is also often employed for the treatment of pulmonary arterial hypertension and benign prostatic hyperplasia [5][6].

In the third phase of a clinical trial carried out, Cialis was found to restore normal erectile function to 50%-60% of the patients, with 60%-90% success recorded at an intercourse attempt. The patients were administered doses ranging from 5-20 mg [7]. In the real world, most men find this drug highly effective and have given it a thumbs up in terms of its efficacy, ease of use, and tolerability. In fact, it has an average rating of 8.5/10 based on user reviews collected by drugs.com [8]. Cialis is gradually becoming most men’s favorite ED drug because of its long-lasting effect, which spans up to 36 hours. It is worth noting that while the effects of tadalafil last for up to 36 hours, the user will not have an around-the-clock erection for the duration but be able to gain and sustain an erection anytime within the 36-hour period.

Cialis is generally safe and well tolerated, but just like every other medicine, it may pose some side effects. The adverse reactions may be mild or severe, depending on the individual’s body make-up, whether it is taken correctly, or the drugs it is coadministered with. For instance, tadalafil interacts negatively with grapefruit, grapefruit juice and may lead to adverse reactions if both are taken concomitantly [9].

It is important to consult a doctor before taking this drug, as well as report any cases of serious side effects timely.

Combining of These Drugs Together

Combining these drugs is a terrible idea. Cialis, just like other ED meds, such as Viagra and Levitra, is a vasodilator. This means that it dilates the blood vessels and ultimately leads to a decrease in blood pressure. Poppers, on the other hand, also act as vasodilators, and if coadministered with Cialis or its likes, they could cause hypotension, a stroke, fainting, or even death [10].

Furthermore, there’s also an increased risk of contracting sexually transmitted infections (STIs) tied to the concomitant use of Cialis and poppers. This stems from the fact that the euphoric high, which results from the administration of the latter, makes users more open to sexual experimentations that may be risky (for example, having sex without using a condom) [2]. Because poppers often reduce sexual function, most of the users who plan to engage in sexual activities try to balance things up with Cialis.

In a nutshell, both drugs pose no serious harm when taken individually, but there’s an increased risk of adverse reactions when they’re taken together. To be on the safe side, consult your healthcare provider before mixing these drugs if you must.

Poppers and Cialis Side Effects

The side effects of Cialis include headache, nausea, dizziness, and flushing. On the other hand, those associated with Poppers include headaches, giddiness, irregular heartbeat, and light-headedness. When combined together, more serious side effects may occur. They include:

• difficulty breathing;
• the possibility of a heart attack;
• a stroke;
• some organ failure;
• heart palpitations.

Furthermore, more side effects may arise, depending on the mode poppers are administered. For example, swallowing it may burn the throat and lead to other serious complications.

It is worth noting that every single drug, on its own, may cause adverse reactions. Thus, it becomes important to consult your doctor before using these drugs individually or combining them.

Can This Combination Cause Death?

Yes, a combination of these drugs can cause death if care is not taken.

Cialis on its own, by virtue of its vasodilating characteristics, reduces blood pressure. As a result, it is not to be combined with other drugs that have a similar effect, as this can lead to hypotension.

Poppers (amyl nitrites, for example) also reduce blood pressure. Thus, if it’s combined with Cialis, especially in high doses, they can cause the blood pressure to drop to dangerously low levels. If this happens for a long period of time, these drugs may lead to shock and then death [9][11].

Withdrawal Time

Through a recent study carried out by Dr. Daniel Demant, poppers are found to have a low-risk profile in terms of dependence. The study, which involved 800 men aged 18-35, showed that they may not, in fact, be addictive in any way and have to link to psychological stress as well as mental health issues [12].

For Cialis, there is no scientific nor medical evidence that points to the fact that it or other medicines used to treat ED are physically addictive. However, Christopher Harte, Ph.D., a researcher, and a postdoctoral fellow at VA Boston Healthcare System, said that it may become psychologically addictive if it is used recreationally [13][14].

Since both drugs are not addictive, they do not have a withdrawal time.

Interaction with Food and Alcohol

Poppers interact with alcohol negatively, and the effects thereof can be harmful. These drugs on their own can temporarily influence brain function, causing hallucinations. Alcohol, on the other hand, can impair memory, slow down reaction time and decision making.

Taking both substances concomitantly over long periods can reduce brain mass and ultimately impair brain function. Furthermore, since both products act like depressants individually, slowing down the central nervous system activity, when combined together, the effects are amplified. This may result in a heart attack, shortness of breath, or even death if left unattended [15].

Cialis, on the other hand, may not interact with alcohol in a way that can cause harm if taken moderately. However, it may affect its efficacy if consumed excessively. This medication interacts with certain drugs like metoprolol, lisinopril, amlodipine, and nitrates such as isosorbide dinitrate or nitroglycerin [16]. It also interacts negatively with grapefruits and grape juice in a way that can increase the risk of harmful side effects.

This does not represent the full range of drugs poppers and Cialis may interact with, so consult a physician to learn more about it.

What Are the Best Places to Buy These Medicines?

While Cialis is available both online and offline in brick-and-mortar drugstores, poppers are currently only available in sex shops as sex enhancers and as room deodorizers. Certain online platforms may also have them listed, but care should be taken when making purchases.

Most users prefer buying drugs from reliable online drugstores because of the associated ease and speed of delivery. Here are some of the best online platforms you can get Cialis as well as other ED medicines from.

ViaBestBuys

This is a very popular vendor with lots of positive feedback from its customers online. ViaBestBuys sells Cialis alongside other ED drugs like Levitra and Viagra at a very affordable price. It has a visually appealing website that is easy to navigate and make payments. This vendor accepts credit cards, PayPal, and Bitcoin. It does not require a prescription from buyers to sell.

ViaBestBuys often provides customers with great deals and discounts via coupon codes and vouchers. For instance, it offers as much as 25% discounts to those who use Bitcoin to make payments. This vendor ships all products via two main options:

• Express Mail Service (EMS) is a faster shipping method and the perfect choice for people who have an urgent or pressing need. It usually takes 7-10 business days to deliver orders to countries like Australia, the EU, New Zealand, the United States, and the United Kingdom. Deliveries to other locations may take 14-30 business days.
• Registered Airmail, on the other hand, has a longer delivery time, but it is perfect for fulfilling bulk orders. Packages to be delivered to the aforementioned countries may take between 10-18 business days and 14-30 days to other parts of the world.

While shipping via EMS costs $49 and is completely free for customers who place orders worth $180, that through Registered Airmail costs $39 and is usually free for orders over $130.

ViaBestBuys does not ship to a number of countries, including Brazil, Mexico, Canada, Pakistan, Israel, Saudi Arabia, South Africa, Taiwan, the United Arab Emirates, and Indonesia. However, people in these regions can still get their packages delivered using a parcel forwarding service like Skypax.

This vendor offers customers a full refund or free reshipment for packages delayed at customs for more than 2 weeks or that go missing.

CialisBit

CialisBit shares a lot of similarities with ViaBestBuys in terms of its available payment methods, discounts, and the countries it ships. It also delivers packages using two shipping methods:

• Express Mail Service (EMS). This vendor delivers orders to the EU, Australia, the UK, the USA, and New Zealand within 7-10 business days and those to other parts of the world within 14-30 business days. A tracking number is always issued within 24-72 hours from the time of purchase, and no signature is usually required upon delivery.
• Registered Airmail. This shipping option usually takes between 10-18 business days to deliver orders to the aforementioned countries and 14-30 days to other destinations. It is the perfect method for shipping bulk orders, especially to countries with stringent import laws. Packages sent with this method are not trackable.

Like ViaBestBuys, this vendor also reships lost parcels or those stuck in customs for more than 2 weeks at no extra cost.

There are certain countries where CialisBit does not ship to. They include:

• South Africa;
• the United Arab Emirates;
• Taiwan;
• Israel;
• Brazil;
• Pakistan;
• Indonesia;
• Mexico;
• Indonesia;
• Saudi Arabia;
• Canada.

However, customers residing in these countries or others with strict customs laws can still get Cialis as well as other ED meds delivered to their respective locations if they use Skypax.com

HighStreetPharma

HighStreetPharma does not require a prescription. It offers a wide variety of drugs at pocket-friendly prices. Besides ED meds, this vendor also sells antibacterials, antifungals, antivirals, antidepressants, diuretics as well as drugs for diabetes, cholesterol, cardiovascular diseases, and lots more.

It has lots of fulfillment centers in different parts of the world like Mauritius, India, the United Kingdom, the United States, and New Zealand. This helps facilitate its delivery speed. Like ViaBestBuys and CialisBit, HighStreetPharma also uses Registered Airmail and EMS as its shipping methods. However, while shipments via Registered Airmail takes 14-21 days, those through its EMS service get delivered within 7-14 days.

This vendor’s accepted methods of payment are limited to Bitcoin and Gift Cards. It offers free shipping via Registered Airmail for orders worth $150.

PureRxPills

This vendor has a visually appealing website that is easy to navigate and make payments. It offers a wide range of medications at an affordable price and doesn’t require a medical prescription from intending buyers. It also offers great deals and discounts via coupon codes and vouchers. For example, PureRxPills is currently giving a 20% discount to returning buyers.

PureRxPills makes it possible for customers to shop conveniently without having to bear any risks. This vendor takes the privacy of its clients very seriously and never discloses information such as credit card details, addresses, phone numbers, or even names to any third party for any purpose whatsoever.

With this vendor, 99% of all orders are considered eligible for free global shipping. Packages are dispatched using Registered Airmail. A signature is usually required upon delivery.

Shipping time may vary depending on the location, time of the year, and quantity of goods purchased. This vendor does not provide an estimated time of delivery; however, it reships or offers full refunds if the package arrives damaged or doesn’t arrive at all.

Resume

Cialis is a highly effective drug for treating erectile dysfunction, and it works perfectly for most users when taken correctly. While the majority of men have an urge to experiment or achieve better results, it is important to have it at the back of the mind that mixing tadalafil with poppers or other inhalants may be very harmful. Consult a professional if you feel that Cialis is not providing the results you expect.

References:

1. Poppers – Wikipedia. Retrieved: March 4, 2020. En.wikipedia.org.
2. What are Poppers and are They Safe? By Jayne Leonard. Medically reviewed by Zara Risoldi Cochrane, PharmD, MS, FASCP. Retrieved: March 4, 2020. Medicalnewstoday.com.
3. Side Effects and Dangers of Using Poppers. By Elizabeth Hartney, BSc., MSc., MA, PhD. Medically reviewed by Steven Gans, MD. Retrieved: March 4, 2020. Verywellmind.com.
4. Poppers: What Do They Actually Do to You? By Brian Krans. Medically reviewed by Steve Kim. Retrieved: March 4, 2020. Healthline.com.
5. Cialis (tadalafil) FDA Approval History. Retrieved: March 4, 2020. Drugs.com.
6. High Blood Pressure and Sex: Overcome the Challenges. By Mayo Clinic Staff. Retrieved: March 4, 2020. Mayoclinic.org.
7. Tadalafil in the Treatment of Erectile Dysfunction; An Overview of the Clinical Evidence. By Giovanni Vanni Frajese, Flavio Pozzi, et al. Clin Interv Aging. 2006 Dec; 1(4): 439–449. Retrieved: March 4, 2020. Ncbi.nlm.nih.gov.
8. User Reviews for Tadalafil to treat Erectile Dysfunction. Retrieved: March 4, 2020. Drugs.com.
9. Tadalafil: Side Effects, Dosage, Uses, and Interactions. By University of Illinois-Chicago, Drug Information Group. Retrieved: March 4, 2020. Healthline.com.
10. Viagra and Poppers Dangers | Go Ask Alice! By Alice. Retrieved: March 4, 2020. Goaskalice.columbia.edu.
11. Can You Die From Low Blood Pressure? By Benjamin Wedro, MD, FACEP, FAAEM. Medically Reviewed By Melissa Conrad Stöppler, MD. Retrieved: March 4, 2020. Emedicinehealth.com.
12. New Research Backs TGA Decision on Poppers | University of Technology Sydney (UTS). Retrieved: March 4, 2020. Uts.edu.au.
13. Can Recreational ED Drug Use Lead to ED? By Kathleen Doheny. Retrieved: March 4, 2020. Webmd.com.
14. Is Viagra Dependency a Thing? Retrieved: March 4, 2020. Forhims.com.
15. What Happens When You Mix Inhalants and Alcohol? Retrieved: March 4, 2020. Therecoveryvillage.com.
16. Cialis Drug Interactions. Retrieved: March 4, 2020. Drugs.com.