Viagra and Ibuprofen: Is It Safe to Mix?

Viagra is a famous remedy for impotence that’s been dubbed as the “little blue pill.” As the first erectile dysfunction (ED) medication to be approved by the Food and Drug Administration (FDA), it has had extensive scientific research about its effects and safety.

Another drug, Ibuprofen, is widely prescribed to combat fever & mild to severe pain due to certain health problems including migraines, painful menstrual periods, & rheumatoid arthritis, among several others.

Is it okay to take Viagra and Ibuprofen together? What happens if these meds are combined? Can this mix affect your health? Since headache and back pain are some of the adverse reactions of Viagra, this guide outlines the outcome of mixing it with Ibuprofen to reduce the mentioned symptoms. We’ll discuss the main features of Ibuprofen, the effects of using it with the ED drug, the possible negative reactions of both tabs, and the withdrawal period.

In the end, we give the best e-pharmacies where you can buy these drugs over the counter to combat ED, pain, or fever caused by many health conditions.

Main Features of Ibuprofen

Ibuprofen is in a class of medications called nonsteroidal anti-inflammatory drugs (NSAIDs). It works by blocking the production of prostaglandins, substances that cause inflammation. Ibuprofen reduces fever and manages mild to moderate pain due to many health conditions such as toothache, headache, back pain, menstrual cramps, arthritis, and minor injury [1]. Doctors also use this drug to treat patent ductus arteriosus (PDA) in premature neonates. In 2017, it became the 28th most commonly prescribed medication in the USA, with about 24 million prescriptions.

Ibuprofen medicine was approved for prescription use by the FDA in 1974. However, in 1984, it gained the over-the-counter (OTC) status. It is considered to be among the safest NSAIDs & is generally well-tolerated in most patients. Nevertheless, this pill rarely causes consequential acute liver injury.

This medication is sold under various brand names (Motrin®, Advil®, and others [2]). It comes in several forms including tablets, capsules, liquids, and gels. It typically begins working within an hour.

What Is Viagra Medicine?

Sildenafil sold by Pfizer Inc. under the brand-name Viagra® is a medication used to treat ED. Its generics (now available after the patent expiry) come in various forms including chewable tablets and oral jelly. Viagra’s onset is typically within 15–20 minutes & its effects last for about 4–5 hours.

This medication is now one of the standard remedies for impotence, including for men with diabetes mellitus [3]. It works like any phosphodiesterase type 5 (PDE5) inhibitor in the body: it blocks the activity of an enzyme known as PDE5. The latter promotes the breakdown of cyclic guanosine monophosphate (cGMP), a chemical substance that regulates blood flow in the penis. It is released with the aid of nitric oxide (NO) that’s produced in the body when a man is sexually stimulated. The cGMP is responsible for softening and smoothening the penile arteries to let blood flow into the penis. Adequate blood circulation in the penile area triggers erections needed for a fulfilled sexual activity.

An interesting history of sildenafil is worth mentioning. Pfizer originally discovered this medication in 1989 while looking for a treatment for heart-related chest pain. The outcome was twofold – a perfect remedy for ED as well as pulmonary arterial hypertension (PAH).

Although Viagra was approved for medical use in the USA & Europe in 1998, it became the 217th most commonly prescribed medication in the U.S. in 2017, with more than 2 million prescriptions. Moreover, in 2017, Viagra became available as a generic medication after the final patents held by Pfizer expired. In the United Kingdom, this medication is available over the counter (OTC).

Viagra’s patent expiry has led to tens of generics to combat ED. The core reasons are the availability of extensive market share and the attempt to address the high cost of Viagra®.

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Can You Mix Ibuprofen and Viagra Together?

Viagra can cause some side effects. Their onset varies from patient to patient: some might not experience them at all, while others might feel some mild symptoms. In rare cases, several negative reactions may require a medical specialist’s help.

Can you take Viagra and Ibuprofen together? Is it safe to mix these drugs? The answer is yes. To be consistent with this guide, headache is a very common negative effect that can occur when taking Viagra & other ED tablets. How can a patient combat this condition? Taking paracetamol or another simple painkiller, such as aspirin or ibuprofen, at the same time as Viagra can help alleviate this symptom. As a precaution, it’s paramount to always read the patient information leaflet given with all meds before administering the drug.

Apart from simple painkillers & using the minimum effective dose to combat headache caused by Viagra, there may be little else alternative to try, except perhaps alternative pills such as Levitra (vardenafil) or Cialis (tadalafil), which may produce less headache. However, Cialis has a longer duration of action than Viagra. If you experience cluster headaches caused by sildenafil, low-dose tadalafil should be considered.

However, to some individuals, the big question remains, Can Ibuprofen cause ED? A 2011 study (published at auajournals.org) speculated that if inflammation can cause ED, then aspirin or NSAIDs like ibuprofen could help prevent this sexual problem. The study summarized that anti-inflammatory meds seemed to cause ED beyond what would be expected due to age & comorbidity. The research also suggested that those who use aspirin & NSAIDs are 20% more likely to have ED [4].

Possible Side Effects of Mixing

While these medicines are safe if combined, some side effects can be experienced, although the mix can lower the onset of muscle pain, headache, and back pain.

According to a study, Viagra can cancel the painkillers’ negative effects but might have some adverse reactions of its own. This medication could be used to block gastric inflammation caused by meds such as aspirin & ibuprofen [5].

As with Viagra, seek medical help immediately if you have signs of an allergic reaction like difficulty breathing, hives, swelling of the face, lips, or tongue. The potential negative effects of sildenafil may include:

• flushing;
• dizziness;
• nausea;
• headache (Ibuprofen can lower);
• abnormal vision;
• nosebleeds;
• sleep problems;
• back pain;
• muscle pain;
• upset stomach.

This is not a complete list of possible negative effects [6]. Refer to the drug leaflet or your doctor for more information.

As with Ibuprofen, its common negative effects are as follows:

• heartburn;
• stomach pain;
• vomiting;
• nausea;
• diarrhea;
• gas;
• constipation.

Not every patient can experience these side effects. When they do occur, they are usually mild. However, people can prevent their appearance by taking the painkiller with food or milk. Serious negative effects can also occur. Most of these risks are uncommon with Ibuprofen & can usually be avoided by taking the med as recommended [7]. If you experience an effect that does not go away after some time, even after stopping the medication, seek medical assistance.

By mixing these meds, the more common side effects can be stomach pain & nausea since both drugs cause these conditions. It’s necessary to consult with a doctor for additional information about the negative reactions to experience if combining the tabs.

Withdrawal Period

Sildenafil is only used for short-term treatment of ED. It may come with serious risks if you don’t take it as recommended. If you stop taking the medicine suddenly or don’t take it at all, your ED symptoms won’t improve. For most men, Viagra, just like any other ED med, must be continued for improvements in erectile function to be maintained. But it’s only taken when needed [8].

Sildenafil usually leaves the body system 2 to 3 hours after ingestion. Depending on the user’s metabolism, this medication can take 5 to 6 hours to fully leave the body system. A higher dosage of Viagra takes longer to leave the body. A 25 mg dose may wear off after a couple of hours, but a 100 mg dose may take nearly 4 times as long to leave the system.

The abuse of Viagra may lead to the development of psychological dependency. The potential of withdrawal symptoms is more likely to be higher when it’s used in combination with other meds. The withdrawal symptoms of Viagra include diarrhea, flushing, dizziness, and others. To minimize them, it’s recommended to gradually reduce the use of Viagra with the help of a medical specialist.

In regards to the time Ibuprofen takes to get out of the body system, it can take up to 24 hours to completely rid the user’s system, even though its effects generally last about 4–6 hours. Its half-life is about 2 hours.

While an individual may begin taking this medication to manage mild to moderate physical pain, this may lead to the risk of developing a tolerance or dependence on the medicine due to feeling as though they cannot function normally without the use of Ibuprofen.

Also, if the user develops an Ibuprofen addiction, he/she may experience mild negative effects if they suddenly discontinue the medication. Because the medicine is not addictive, the withdrawal symptoms are minimal but may include the following:

• agitation;
• headache;
• nausea;
• increased depression, anxiety, and levels of pain.

As to how long you should use an OTC NSAID medicine, it shouldn’t be taken continuously for more than 3 days for fever & 10 days for pain unless a medical specialist instructs you. Such remedies work well in relieving pain, but they’re meant for short-term use.

Interaction of Viagra Plus Ibuprofen with Alcohol & Food

Interactions between certain drugs you take with Viagra or Ibuprofen might be moderate or serious. However, there are no interactions between both remedies [9].

Viagra can potentially lower blood pressure. Coadministering it with ethanol (alcohol) may further boost this effect. Also, there is a likeliness of experiencing symptoms such as lightheadedness, dizziness, fainting, flushing, & heart palpitations. Avoid or limit the use of alcohol (like beer or wine) while being treated with sildenafil.

Most foods work well with Viagra. However, while taking the ED tablet, avoid regular consumption of large amounts of grapefruit or its juice. This fruit can boost the levels of sildenafil in the body & delay its absorption. Furthermore, taking fatty meals before administering Viagra might also cause the drug to take effect more slowly. Ideally, it’s recommended to consume a pill on an empty stomach if you need to experience peak effects at a faster rate without any problems.

Alcohol can increase the risk of stomach bleeding caused by Ibuprofen. Do not mix these substances. If you experience symptoms of bleeding in the stomach or intestines, seek help from a medical specialist [10].

What Are the Best Places to Buy These Drugs OTC?

Both drugs are available as generics, which almost always cost less than brand-name meds – up to 90%+ for generic Viagra meds.

FYI: Sildenafil is one of the most counterfeited medicines sold by illegal online drugstores. However, the availability of rating and review portals depicts how a certain e-pharmacy does its business with its customers. Customer reviews and testimonials are the best verdicts to rely on when searching for the most reliable and trustworthy vendor that sells pharmaceutical products.

The following are the top e-pharmacies that offer Viagra and other ED meds at favorable prices. As for Ibuprofen, they might not stock it, but you can find this medicine in your local pharmacy or at another legit e-drugstore by performing research in Google.

Let’s go through a summary of these top vendors to acquaint with their operations, what customers say about them, their shipping options, and delivery time.

ViaBestBuys.com

Known as VBB, this online pharmacy is the number one ED medication vendor selling Viagra plus several other health remedies to combat ED at extremely low prices. It deals with generics sourced from approved Indian manufacturers and ships them worldwide except a few countries listed on its “Shipping FAQ” page.

ViaBestBuys does not require a doctor’s prescription; however, it encourages customers to consult with a medical specialist before ordering the meds.

The pricing of Viagra coupled with coupons, discounts, and offers favors every buyer. The highest discount available is 25% off the buyer’s total cost when checking out using Bitcoin as the payment option. This is the greatest shopping experience you should consider. Besides, the more pills you order from the pharmacy, the lower the cost (less than a dollar per Viagra tablet). Furthermore, VBB provides free ED pills samples. Every order on this e-drugstore comes with a total of 30 free tabs of generic Viagra, Cialis, & Levitra at no extra charge. In addition, the e-pharmacy has a secure 128-bit SSL payment. Easily pay using cryptocurrency, PayPal, and major credit cards.

Shipping is every buyer’s concern. Luckily, VBB offers guaranteed delivery within a timeframe you choose from its available shipping methods as listed below:

• Express Mail Service (EMS): It takes from 7 up to 12 business days for orders from the EU, Australia, New Zealand, the USA, & the UK and 14 to 30 days for other countries this vendor ships to.
• Registered Airmail: It takes 10 up to 18 business days for orders from the EU, Australia, New Zealand, the USA, & the UK and 14 to 30 days for the rest of the world.

This vendor also provides free EMS shipping on every order over $180 or free standard delivery on orders worth $130 or more. In the rare event that the buyer parcel gets lost in transit or stuck in customs, the supplier will either resend the parcel free of charge or offer a full refund.

CialisBit.com

As the name suggests, this vendor is popular for its ED medications such as Cialis, Viagra, and several other brands sold at the best prices. It’s the cheapest supplier for everyone who wants to purchase generic ED tabs while looking for ways to save more.

CialisBit is a legit & reliable online pharmacy with a higher percentage of positive reviews, testimonials, and an excellent rating on Trustpilot.com – just like VBB! When you buy Viagra online from this vendor, you don’t need to take the hard task of submitting a prescription, although having a chat with your medical specialist is highly recommended.

CialisBit shopping experience is protected with a secure 128-bit SSL payment. Safely shop and pay using bitcoin (get a 25% discount), PayPal, & major credit cards. While there are fake e-pharmacies selling counterfeits at extremely low prices, this vendor ensures that the purity & potency of generic ED pills are consistent with that of the branded versions by sourcing them from FDA approved manufacturers. Want to test their quality? Enjoy this vendor’s free Viagra samples. Every order on this e-pharmacy comes with a total of 30 free tabs of generic Viagra, Cialis, & Levitra.

This seller offers fast shipping & it sends buyer parcels in discreet packaging. The tracking number is given after the package shipping starts, and it’s easy to track the parcel every step of the way. As for the shipping methods, CialisBit provides EMS and Registered Airmail. While the former takes from 7 up to 12 business days for orders from the EU, Australia, New Zealand, the USA, & the UK, the latter takes 10 up to 18 business days for the mentioned countries. Deliveries to other parts of the world may take 14–30 workdays, irrespective of the selected shipping option.

The e-pharmacy also provides free express shipping on orders over $180 or free standard delivery on those worth $130 or more. It also offers a 100% refund or a free reshipment if your order is lost in transit or gets stuck in customs. Like VBB, CialisBit ships to most parts of the world except Brazil, Mexico, and a few other countries including Israel, South Africa, and the United Arab Emirates as depicted on its “Shipping FAQ” page. Please confirm if it can ship to your country.

HighStreetPharma.com

HighStreetPharma connects customers with the most trusted sources of generic & branded drug suppliers globally. This vendor cooperates with the most reliable pharmaceutical companies & the quality of the meds it offers is strictly selected by its suppliers. Customer satisfaction is HighStreetPharma’s top priority. All its products are reasonably priced.

Furthermore, unlike VBB and CialisBit that specialize only in ED meds and nootropics, HighStreetPharma online pharmacy store offers the largest selection of health remedies other than the ED category. Each of the generic drugs from this vendor is sold at rock-bottom prices. With its excellent operations, the drugstore has a secured shopping experience, flexible payment options, and the fastest parcel shipping.

At the moment, it has two delivery methods:

• EMS that takes 7–14 business days;
• Airmail service that takes 14–21 days. The parcels sent by this method are not trackable & take a maximum of 30 days to be delivered – depending on your country.

Please note that due to strict country-specific customs laws, HighStreetPharma doesn’t provide refunds or reshipments for several countries listed on its website including Algeria, Belgium, Austria, Armenia, and some more. Please confirm if your country is added to the list before ordering from the vendor.

HighStreetPharma offers free Airmail shipping on orders costing $150+. It also gives a 20% discount to a returning customer. As for the payment options, it accepts credit cards such as gift cards and cryptocurrency.

Conclusion

Viagra and Ibuprofen are safe if mixed together. While the individual drug negative effect can occur, Viagra causes headaches – a very common adverse reaction of sildenafil & other ED tablets. If this is your concern and gets a recommendation from a medical specialist for a safe medication, you can take a painkiller such as Ibuprofen at the same time as Viagra. Take note that mixing drugs without a doctor’s approval is a risk and not recommended. This experience can be very harmful to your health since it can cause severe interactions.

References:

1. Ibuprofen. Retrieved: September 11, 2020. Wikipedia.org.
2. Ibuprofen brand names. Retrieved: September 11, 2020. Wikipedia.org.
3. Sildenafil. Retrieved: September 11, 2020. Wikipedia.org.
4. Regular Nonsteroidal Anti-Inflammatory Drug Use and Erectile Dysfunction. By Joseph M. Gleason, Jeffrey M. Slezak, and others. Published: 2010. Auajournals.org.
5. Viagra cancels painkiller side effects, but might have side effects of its own. By Helen Carmichael. Published: October 28, 2005. Chemistryworld.com.
6. Viagra Side Effects: Common, Severe, Long Term. Retrieved: September 11, 2020. Drugs.com.
7. Ibuprofen (Advil) Side Effects: What You Need to Know. Medically reviewed by Alan Carter, Pharm.D. Written by University of Illinois. Updated: March 7, 2019. Healthline.com.
8. Long-term efficacy and safety of oral Viagra (sildenafil citrate) in men with erectile dysfunction and the effect of randomized treatment withdrawal. By E. Christiansen, W. R. Guirguis, D. Cox, I. H. Osterloh, Sildenafil Multicentre Study Group. Published: June 2000. Pubmed.ncbi.nlm.nih.gov.
9. Drug Interactions Between Ibuprofen and Viagra. Retrieved: September 11, 2020. Drugs.com.
10. Ibuprofen and Alcohol / Food Interactions. Retrieved: September 11, 2020. Drugs.com.